jason shapiro, md

Research is an integral part of our Pediatric GI fellowship program. Prior fellows have successfully taken advantage of a myriad of opportunities offered through the Warren Alpert Medical School and School of Public Health at Brown University. Additional training and research support is available at our Lifespan Biostatistics Core and Advanced Center for Translational Research (CTR). The fellowship program supports an environment of academic curiosity and encourages fellows to seek out projects that fit their specific interests. With access to a wide range of resources, opportunities exist for our fellows to conduct meaningful clinical, translational and basic science research during their three years of training. Rhode Island’s unique geography offers access to population-based cohorts of patients from our multidisciplinary programs including inflammatory bowel disease, Celiac disease, liver disease, eosinophilic GI disorders and functional GI conditions. We also have a strong clinical and academic relationship with colleagues in Child Psychology which offers access to a range of meaningful research opportunities. Mentorship is incredibly important to a successful research experience. As such, our fellows have access to a variety of mentors within the division of Pediatric GI, department of Pediatrics and outside our department as well. Prior fellows have worked with NIH-funded mentors in adult GI, immunology and psychology. To assess progress, fellows will meet with their scholarship oversight committee (SOC) quarterly in years 2 and 3. Furthermore, research updates are presented to the division at regular intervals. Our fellows are also encouraged to present their work at institutional, regional and national meetings. 

research curriculum

Offered through the Department of Emergency Medicine, this quarterly seminar is open to all trainees in the Department of Pediatrics.  The objectives of the curriculum include understanding of the principles of conducting and reviewing academic research, designing and defending a study, learning various analytical tools for data presentation, developing skills necessary for writing a quality manuscript in a timely manner, and emphasizing the ethical principals in conducting research

teaching opportunities

During training, our fellows engage in a variety of teaching opportunities. Fellows are expected to teach medical students and residents on a daily basis while on inpatient service.  They also lead structured teaching sessions throughout the year, including weekly pediatric GI conferences, pediatric residency noon conferences, and multidisciplinary conferences with other specialties.  Fellows have the opportunity to present at pediatric grand rounds and regional conferences.  Our fellows’ posters are routinely presented at NASGPHAN’s annual conference and our fellows have been featured for oral presentations at international conferences including DDW.  In recognition of their commitment to medical education, our fellows have been elected to the Gold Humanism in Medicine Foundation and are the recipients of teaching awards within Brown University.  

Recent publications

  • North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper on the Diagnosis and Management of Pediatric Acute Liver Failure.
    Squires JE, Alonso EM, Ibrahim SH, Kasper V, Kehar M, Martinez M, Squires RH.J Pediatr Gastroenterol Nutr. 2021 Aug 3.
  • Immunoglobulin A Targets a Unique Subset of the Microbiota in Inflammatory Bowel Disease.
    Shapiro JM, de Zoete MR, Palm NW, Laenen Y, Bright R, Mallette M, Bu K, Bielecka AA, Xu F, Hurtado-Lorenzo A, Shah SA, Cho JH, LeLeiko NS, Sands BE, Flavell RA, Clemente JC.  Cell Host Microbe. 2021 Jan 13;29(1):83-93.e3.
  • Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease.
    Ta AD, Ollberding NJ, Karns R, Haberman Y, Alazraki AL, Hercules D, Baldassano R, Markowitz J, Heyman MB, Kim S, Kirschner B, Shapiro JM, Noe J, Oliva-Hemker M, Otley A, Pfefferkorn M, Kellermayer R, Snapper S, Rabizadeh S, Xavier R, Dubinsky M, Hyams J, Kugathasan S, Jegga AG, Dillman JR, Denson LA.  Inflamm Bowel Dis. 2021 Jan 16.
  • Lymphoma in Pediatric-Onset Inflammatory Bowel Disease Treated with Infliximab Monotherapy: A Case Series.  Llanos-Chea A, Shapiro JM, Winter RW, Jerger L, Menz T, Gibson M, Friedmann AM, Treaba D, Papamichael K, Cheifetz AS, Friedman S, Hamilton MJ, Winter HS.  Dig Dis Sci. 2021 Feb 17. 
  • Pediatric Endoscopy in the Era of Coronavirus Disease 2019: A North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper.  Walsh CM, Fishman DS, Lerner DG; NASPGHAN Endoscopy and Procedures Committee#.  J Pediatr Gastroenterol Nutr. 2020 Jun;70(6):741-750.
  • Challenges and Approaches to Assessing Medication Adherence in Pediatric Inflammatory Bowel Diseases.  Barker DH, Shapiro JM, Lobato D, McQuaid EL, Leleiko NS.  J Pediatr Gastroenterol Nutr. 2020 Jun;70(6):759-761.
  • Negative childhood experiences and disordered eating in adolescents in a weight management program: The role of depressive symptoms.  Darling KE, Ranzenhofer LM, Hadley W, Villalta D, Kasper V, Jelalian E.  Eat Behav. 2020 May 22;38:101402.
  • Constipation.  LeLeiko NS, Mayer-Brown S, Cerezo C, Plante W.Pediatr Rev. 2020 Aug;41(8):379-392.
  • Longitudinal non-adherence predicts treatment escalation in paediatric ulcerative colitis.  Carmody JK, Plevinsky J, Peugh JL, Denson LA, Hyams JS, Lobato D, LeLeiko NS, Hommel KA.  Aliment Pharmacol Ther. 2019 Oct;50(8):911-918.
  • Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort.  Perler B, Ungaro R, Baird G, Mallette M, Bright R, Shah S, Shapiro J, Sands BE.  BMC Gastroenterol. 2019 Apr 2;19(1):47.
  • Knowledge, Attitudes, and Behaviors of Pediatric Primary Care Providers on Management of Cholestasis.  Menz TJ, Herzlinger M, Ross A, Zonfrillo MR.  Glob Pediatr Health. 2019 Feb 26;6:2333794X19829757.
  • Utility of 15(S)-HETE as a Serological Marker for Eosinophilic Esophagitis.  Lu S, Herzlinger M, Cao W, Noble L, Yang D, Shapiro J, Kurtis J, LeLeiko N, Resnick M.  Sci Rep. 2018 Sep 28;8(1):14498.
  • Multidisciplinary care considerations for gender nonconforming adolescents with eating disorders: A case series.  Donaldson AA, Hall A, Neukirch J, Kasper V, Simones S, Gagnon S, Reich S, Forcier M.  Int J Eat Disord. 2018 May;51(5):475-479.
  • Roux-en-Y enterolith leading to obstruction and ischemic necrosis after pediatric orthotopic liver transplantation.  Quillin RC 3rd, Bongu A, Kasper V, Vittorio JM, Martinez M, Lobritto SJ, Griesemer AD, Guarrera JV.  Pediatr Transplant. 2018 May;22(3):e13160.
  • Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort.  Shaw KA, Cutler DJ, Okou D, Dodd A, Aronow BJ, Haberman Y, Stevens C, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery S, Dubinsky MC, Shapiro JM, Otley AR, Daly M, Denson LA, Kugathasan S, Zwick ME.  Genes Immun. 2019 Feb;20(2):131-142.
  • Biologics Delay Progression of Crohn’s Disease, but Not Early Surgery, in Children.  Kerur B, Machan JT, Shapiro JM, Cerezo CS, Markowitz J, Mack DR, Griffiths AM, Otley AR, Pfefferkorn MD, Rosh JR, Keljo DJ, Boyle B, Oliva-Hemker M, Kay MH, Saeed SA, Grossman AB, Sudel B, Kappelman MD, Schaefer M, Tomer G, Bousvaros A, Lerer T, Hyams JS, LeLeiko NS.  Clin Gastroenterol Hepatol. 2018 Sep;16(9):1467-1473.